BDBM486542 20::US10947251, Example 19

SMILES COc1cc(cc(F)c1N1[C@@H]2CCN(C[C@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=MGYYQTMVKDWCEY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 486542   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM486542(20 | US10947251, Example 19)
Affinity DataIC50: 831nMAssay Description:Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM486542(20 | US10947251, Example 19)
Affinity DataIC50: 50nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent