68 articles for thisTarget
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Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
University of North Carolina At Chapel Hill
Structure-Activity Relationships and Kinetic Studies of Peptidic Antagonists of CBX Chromodomains.
University of North Carolina At Chapel Hill
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
University of North Carolina At Chapel Hill
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.
University of North Carolina At Chapel Hill
Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.
University of North Carolina At Chapel Hill
Telomere maintenance as a target for drug discovery.
University of North Carolina At Chapel Hill
Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors.
University of North Carolina At Chapel Hill
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
University of North Carolina At Chapel Hill
Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.
University of North Carolina At Chapel Hill
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.
University of North Carolina At Chapel Hill
Colloidal aggregation causes inhibition of G protein-coupled receptors.
University of North Carolina At Chapel Hill
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.
University of North Carolina At Chapel Hill
Structure-functional selectivity relationship studies ofß-arrestin-biased dopamine D2 receptor agonists.
University of North Carolina At Chapel Hill
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
University of North Carolina At Chapel Hill
Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers.
University of North Carolina At Chapel Hill
Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compounds.
University of North Carolina At Chapel Hill
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
University of North Carolina At Chapel Hill
Small-molecule ligands of methyl-lysine binding proteins.
University of North Carolina At Chapel Hill
Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.
University of North Carolina At Chapel Hill
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
University of North Carolina At Chapel Hill
BRACO19 analog dimers with improved inhibition of telomerase and hPot 1.
University of North Carolina At Chapel Hill
Fused Tetrahydroquinolines Are Interfering with Your Assay.
University of North Carolina At Chapel Hill
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.
University of North Carolina At Chapel Hill
PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas.
University of North Carolina At Chapel Hill
Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore.
University of North Carolina At Chapel Hill
Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol.
University of North Carolina at Chapel Hill
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.
University of North Carolina At Chapel Hill
In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases.
University of North Carolina At Chapel Hill
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
University of North Carolina At Chapel Hill
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.
University of North Carolina At Chapel Hill
Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial
University of North Carolina At Chapel Hill
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
University of North Carolina At Chapel Hill
UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
University of North Carolina At Chapel Hill
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes.
University of North Carolina At Chapel Hill
Design and evaluation of 1,2,3-dithiazoles and fused 1,2,4-dithiazines as anti-cancer agents.
University of North Carolina At Chapel Hill
C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists.
University of North Carolina At Chapel Hill
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
University of North Carolina At Chapel Hill
Utilizing comprehensive and mini-kinome panels to optimize the selectivity of quinoline inhibitors for cyclin G associated kinase (GAK).
University of North Carolina At Chapel Hill
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
University of North Carolina At Chapel Hill
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D
University of North Carolina At Chapel Hill
Drugs for the Treatment of Zika Virus Infection.
University of North Carolina At Chapel Hill
Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
University of North Carolina At Chapel Hill
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
University of North Carolina At Chapel Hill
Anti-AIDS (acquired immune deficiency syndrome) agents. 17. New brominated hexahydroxybiphenyl derivatives as potent anti-HIV agents.
University of North Carolina At Chapel Hill
A molecular target for suppression of the evolution of antibiotic resistance: inhibition of the Escherichia coli RecA protein by N(6)-(1-naphthyl)-ADP.
University of North Carolina At Chapel Hill
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
University of North Carolina At Chapel Hill
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents.
University of North Carolina At Chapel Hill
Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.
University of North Carolina At Chapel Hill
1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
St. Jude Children''S Research Hospital
SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.
Sanofi-Synthelabo Research
Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.
Eli Lilly
In vitro and in vivo pharmacological characterization of N6-cyclopentyl-9-methyladenine (N-0840): a selective, orally active A1 adenosine receptor antagonist.
Whitby Research
Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Istanbul University
Optimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists and discussion of their binding modes.
Astellas Pharma
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.
Schering-Plough Research Institute
Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors.
Hawaii Biotech
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
University of Newcastle